issue能用of吗

可以用，例如：

1、This isn't very important ─ I don't want to make an issue of it.这不太重要——我不想把它当回事儿。

2、The issue of terrorism is back on the radar screen.恐怖主义问题重新受人关注。

3、Talks between management and workers broke down over the issue of holiday pay.劳资双方就假日工资的谈判破裂了。

issue能用of吗

在这里“issue”意思是“问题”，“of”后面通常加名词，意思是“关于••••••的问题”、“在关于••••••问题上”，例如on the issue of clothing，关于服装问题。